GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP Research Proposal

GENETIC VARIATION IN B-TYPE NATRIURETIC PEPTIDE PATHWAY AFFECTS BNP LEVEL in the diagnosis of Heart failure - Research Proposal Example To help establish the outcomes, the study will be embedded on extracting DNA samples from 80 patients undergoing elective cardiac catheterization and analyzing with exclusion done on patients with elevated troponin. This will be driven by a detailed data collection including laboratory, standard demographic, catheterization and echocardiographic data. The Genotype will be evaluated at 19 loci on five BNP’s pathway relevant genes (Knowles, Erickson, Guy et al, 2003). To access the incremental influence of the genetic variants, the researcher will employ the Multivariate linear regression of logBNP model adjusted for clinical variables. The proposal will thus try to help properly incorporate the use of NPs to improve the levels of accuracy with respect to decisions made in an emergency setting to curb the missed incidence of diagnostic failures for HF. This will be measured by reduced cases of fatigue, dyspnea, and fluid retention that are all predisposing factors to HF based on cardiac dysfunction hence presenting difficulties in diagnosing HF. The missed incidence are hence strongly correlate to highly significant mortality increases, presenting the need for designing effective diagnostic tools with higher degrees of specification and sensitivity that if employed, can help weed out the increased cases of HF missed diagnose s and particularly, in the busy Heart failure is characterized by its typical but non-specific symptoms like fatigue, dyspnea and fluid retention caused by dysfunction of cardiac which present daunting challenges for diagnosis of HF culminating into increased missed incidence hence higher mortality rates. For this reason, the topic has captured the attention of various researchers to help design effective mechanism and approaches that can be used during diagnosis to detect this catastrophic cardiovascular disease quickly and accurately. For instance, to gauge the potentiality of NPs in augmenting the clinical judgment and/or standard

Surveillance Soceity (pro and cons) Essay Example | Topics and Well Written Essays - 750 words - 1

Surveillance Soceity (pro and cons) - Essay Example This essay therefore looks at two sides of an argument about the pros and cons of having surveillance society based on the theory of surveillance and privacy. On the whole, those who argue for surveillance society are those who take the moral side of the debate, having the main conclusion that the guarantee for having the right thing done should come ahead of any personal and individual rights and privileges.4 The major reason that is cited to back this argument is that the world becomes safer and get criminals accounting for their deeds when there is maximum surveillance.5 Typical evidence that can be used to support this is the case of Trayvon Martin who was fatally shot by George Zimmerman. Indeed in the course of the trial, evidence from eye witnesses could not prove credible enough for the eventual judgment to be accepted by both sides. This is because there were variations in accounts given as to what happened.6 In such a case, a person reasoning from a moral perspective would just wish there was a means to hit rewind, something that can only be made possible if any of the two people involved wore a personal recording device.7 From the above, the premise stated is that a surveillance society is one that guarantees the safety of the people and protects them from the hands of evil people who would want to commit crimes and have their ways with them. With the example give, an unstated assumption is that should all people wear personal recording devices, the issue of evidence in court would be more credible. By inference, our current society will become more secure and most forms of legal tussles that take years to hear in court would become a thing of the past.8 As the legal process functions largely on evidence, it is expected that such forms of evidence that come through surveillance equipment in society would set the pace for having a better evidence based judgment.9 The other side of the argument which is against surveillance society is commonly upheld by